Marc Betoule completed his undergraduate studies at the Institut Supérieur de l'aéronautique et de l'espace (SUPAERO) in Toulouse. He moved on to his graduate studies in Paris and started his research on observationnal cosmology under the supervision of Jacques Delabrouille in the context of the preparation of the Planck mission. He defended his Phd thesis in 2009 on the subject of component separation for Cosmic Microwave Background datasets.
When joining the Paris Supernova Cosmology Group at LPNHE, he turned to studying another cosmological probe constraining the dark energy: type Ia supernova. He is involved in the data reduction of the Supernova Legacy Survey (SNLS) and a joint analysis of these data with those of the Sloan Digital Sky Survey.